The N-terminus of MIF controls the flexibility of specific β-sheet residues resulting in dynamic regulation of CD74 activation

Macrophage migration inhibitory factor (MIF) is a pleiotropic protein with catalytic, CD74, CXCR2, CXCR4, and nuclease activities that contribute to the pathology of various inflammatory disorders, cardiovascular diseases, cancer. The majority MIF-triggered pathological conditions are associated activation MIF’s cell surface receptor. mechanistic details MIF-induced CD74 were mostly unknown until recently where it was shown intramolecular dynamic signals transmitted from an allosteric center regulate site on surface.